人用保肝药物对兽医临床的启示
<P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> 在家禽的养殖过程中,由于药物,饲料中的霉菌毒素,和病毒等因素对等对肝脏的刺激,导致肉鸡肝病越来越不容忽视。有时在治疗的的过程中,加一点保肝药物就会降低死亡率。所以传统的治疗中只注意护肾而忽视保肝的方法已不能适应疾病的发展。如果肝脏有病就会引发肾病的发生,所以在治疗疾病的过程中,保肝护肾已显得相当重要。特别是在治疗流感继发的气囊炎,加一些保肝护肾的药物会有出其不意的效果,远比单一通肾疗效要好的多。保肝药物是指对肝细胞损伤具有一定保护作用的药物,引起肝细胞损伤的病因有很多,因此,在保肝治疗中,首先应去除病因,然后再进行保肝药物治疗,方能奏效,</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">。现将常用保肝药物介绍如下,以备广大兽医工作者参考:<SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>1</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.必需磷脂类:是细胞膜的重要</SPAN>内该药物的清除</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">组分,促进肝细胞膜再生、协调磷脂和细胞膜功能、降低脂肪浸润,如多磷脂酰胆碱(易善复)。口服或静脉给药均吸收迅速,经肝代谢,大部分为机体利用,代谢物自尿排出。 </SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"></SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>2</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.解毒类药物:可以提供巯基或葡萄糖醛酸,增强解毒功能,如葡醛内酯(肝泰乐)、谷胱甘肽(松泰斯、古拉定、阿拓莫兰、绿汀诺等)、硫普罗宁(凯西莱)。还原型谷胱甘肽主要在肝脏合成,广泛分布于各组织器官,它与体内过氧化物和自由基自由结合,对抗氧化剂对巯基的破坏,保护细胞中含巯基的蛋白和酶,对抗氧化剂对巯基的破坏,保护细胞中含巯基的蛋白和酶,对抗其对脏器的损伤。硫普罗宁(凯西莱)可以提供巯基、解毒、抗组胺和清除自由基,保护肝细胞。而在兽医临床中多用葡醛内酯。</SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>3</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.抗炎类药物:有类激素作用,主要为甘草甜素制剂,如发放甘草酸胺(强力宁)、甘草酸二胺(甘利欣)、复方甘草甜素(美能)等。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US><o:p></o:p></SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>4</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.利胆类药物:腺苷蛋氨酸(思美泰)是人体所有体液中的活性物质,作为甲基提供的前体参与重要生化反应,在肝内有助于防止胆汁淤积。熊去氧胆酸(优思弗)是正常胆汁成分的异构体,可增加胆汁分泌,抑制肝脏胆固醇合成,减少肝脏脂肪,松弛</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>Oddi</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">括约肌,促进胆石溶解和胆汁排出。严。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US><o:p></o:p></SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>5</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.生物制剂:如肝细胞生长因子。促进肝细胞再生,多用于重症肝炎。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US><o:p></o:p></SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>6</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.降酶药物:均为合成五味子丙素时的中间体,对细胞色素</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>P450</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">酶活性有明显诱导作用,</SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"></SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>7</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.维生素及辅酶类:能够促进能量代谢,保持代谢所需各种酶的正常活性,主要包括各种水溶性维生素,如维生素</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>C</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">、维生素</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>B</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">及辅酶</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>A</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">等。脂溶性维生素剂量大时,可能加重肝脏负担,一般不用。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US><o:p></o:p></SPAN></P><P style="TEXT-ALIGN: left; LINE-HEIGHT: 21pt; MARGIN: 15pt; mso-pagination: widow-orphan" class=MsoNormal align=left><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt"> </SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US>8</SPAN><SPAN style="FONT-FAMILY: 宋体; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt">.中草药:祖国传统医学对急慢性肝病的治疗均有独到之处,五味子、茵陈、垂盆草等药物均有明显保肝降酶功效,许多方剂安全有效,临床应用很广,如茵栀黄等。中草药保肝药物在兽医临床中的运用值得大力开发。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: #1e1e1e; mso-bidi-font-size: 10.5pt; mso-font-kerning: 0pt" lang=EN-US><o:p></o:p></SPAN></P> 写的很好。。。。。。
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